Theme-based Research Scheme, UGC, Hong Kong (T11-705/21-N)
PUBLICATION
2022
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Hui KPY, Ho JCW, Cheung MC, Ng KC, Ching RHH, Lai KL, Kam TT, Gu H, Sit KY, Hsin MKY, Au TWK, Poon LLM, Peiris M, Nicholls JM, Chan MCW. SARS-CoV-2 Omicron variant replication in human bronchus and lung ex vivo. Nature. 2022 Mar;603(7902):715-720. doi: 10.1038/s41586-022-04479-6. Epub 2022 Feb 1.
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Yen HL, Sit THC, Brackman CJ, Chuk SSY, Gu H, Tam KWS, Law PYT, Leung GM, Peiris M, Poon LLM; HKU-SPH study team. Transmission of SARS-CoV-2 delta variant (AY.127) from pet hamsters to humans, leading to onward human-to-human transmission: a case study. Lancet. 2022 Mar 12;399(10329):1070-1078. doi: 10.1016/S0140-6736(22)00326-9.
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Ma Z, Li X, Fan RLY, Yang KY, Ng CSH, Lau RWH, Wong RHL, Ng KK, Wang CC, Ye P, Fu Z, Chin AWH, Lai MYA, Huang Y, Tian XY, Poon LLM, Lui KO. A human pluripotent stem cell-based model of SARS-CoV-2 infection reveals an ACE2-independent inflammatory activation of vascular endothelial cells through TLR4. Stem Cell Reports. 2022 Mar 8;17(3):538-555. doi: 10.1016/j.stemcr.2022.01.015. Epub 2022 Feb 17.
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Ahmed SF, Sohail MS, Quadeer AA, McKay MR. Identification of Potential SARS-CoV-2 CD8+ T Cell Escape Mutants. Vaccines (Basel). 2022 Mar 31;10(4):542. doi: 10.3390/vaccines10040542.
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Cheng SMS, Mok CKP, Leung YWY, Ng SS, Chan KCK, Ko FW, Chen C, Yiu K, Lam BHS, Lau EHY, Chan KKP, Luk LLH, Li JKC, Tsang LCH, Poon LLM, Hui DSC, Peiris M. Neutralizing antibodies against the SARS-CoV-2 Omicron variant BA.1 following homologous and heterologous CoronaVac or BNT162b2 vaccination. Nat Med. 2022 Mar;28(3):486-489. doi: 10.1038/s41591-022-01704-7. Epub 2022 Jan 20.
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Mok CKP, Chen C, Yiu K, Chan TO, Lai KC, Ling KC, Sun Y, Hui DS, Cheng SMS, Peiris M. A Randomized Clinical Trial Using CoronaVac or BNT162b2 Vaccine as a Third Dose in Adults Vaccinated with Two Doses of CoronaVac. Am J Respir Crit Care Med. 2022 Apr 1;205(7):844-847. doi: 10.1164/rccm.202111-2655LE.
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Mok CKP, Cohen CA, Cheng SMS, Chen C, Kwok KO, Yiu K, Chan TO, Bull M, Ling KC, Dai Z, Ng SS, Lui GC, Wu C, Amarasinghe GK, Leung DW, Wong SYS, Valkenburg SA, Peiris M, Hui DS. Comparison of the immunogenicity of BNT162b2 and CoronaVac COVID-19 vaccines in Hong Kong. Respirology. 2022 Apr;27(4):301-310. doi: 10.1111/resp.14191. Epub 2021 Nov 24.
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Hui DSC, Zumla A. Advances in the epidemiology, clinical features, diagnosis, clinical management and prevention of coronavirus disease 2019. Curr Opin Pulm Med. 2022 May 1;28(3):166-173. doi: 10.1097/MCP.0000000000000875. Epub 2022 Mar 9.
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Niederman MS, Zumla A. Editorial: Coronavirus disease 2019 (COVID-19) - advances in epidemiology, diagnostics, treatments, host-directed therapies, pathogenesis, vaccines, and ongoing challenges. Curr Opin Pulm Med. 2021 May 1;27(3):141-145. doi: 10.1097/MCP.0000000000000771.
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Hachim A, Gu H, Kavian O, Mori M, Kwan MYW, Chan WH, Yau YS, Chiu SS, Tsang OTY, Hui DSC, Mok CKP, Ma FNL, Lau EHY, Amarasinghe GK, Qavi AJ, Cheng SMS, Poon LLM, Peiris JSM, Valkenburg SA, Kavian N. SARS-CoV-2 accessory proteins reveal distinct serological signatures in children. Nat Commun. 2022 May 26;13(1):2951. doi: 10.1038/s41467-022-30699-5.
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Cheng SM, Mok CKP, Chan KC, Ng SS, Lam BH, Luk LL, Ko FW, Chen C, Yiu K, Li JK, Chan KK, Tsang LC, Poon LL, Hui DS, Peiris M. SARS-CoV-2 Omicron variant BA.2 neutralisation in sera of people with Comirnaty or CoronaVac vaccination, infection or breakthrough infection, Hong Kong, 2020 to 2022. Euro Surveill. 2022 May;27(18):2200178. doi: 10.2807/1560-7917.ES.2022.27.18.2200178.
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Gu H, Ng DYM, Liu GYZ, Cheng SSM, Krishnan P, Chang LDJ, Cheuk SSY, Hui MMY, Lam TTY, Peiris M, Poon LLM. Recombinant BA.1/BA.2 SARS-CoV-2 Virus in Arriving Travelers, Hong Kong, February 2022. Emerg Infect Dis. 2022 Jun;28(6):1276-1278. doi: 10.3201/eid2806.220523. Epub 2022 Apr 8.
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Chin AWH, Lai AMY, Peiris M, Man Poon LL. Increased Stability of SARS-CoV-2 Omicron Variant over Ancestral Strain. Emerg Infect Dis. 2022 Aug;28(7):1515-1517. doi: 10.3201/eid2807.220428. Epub 2022 May 12.
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Su W, Choy KT, Gu H, Sia SF, Cheng KM, Nizami SIN, Krishnan P, Ng YM, Chang LDJ, Liu Y, Cheng SM, Peiris M, Poon LL, Nicholls JM, Yen HL. Omicron BA.1 and BA.2 sub-lineages show reduced pathogenicity and transmission potential than the early SARS-CoV-2 D614G variant in Syrian hamsters. J Infect Dis. 2022 Jul 1:jiac276. doi: 10.1093/infdis/jiac276. Epub ahead of print.
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Chan KKP, Hui DSC. Contemporary Concise Review 2021: COVID-19 and other respiratory infections. Respirology. 2022 Aug;27(8):661-668. doi: 10.1111/resp.14305. Epub 2022 Jun 7.
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Yuan L, Zhu H, Zhou M, Ma J, Liu X, Wu K, Ye J, Yu H, Chen P, Chen R, Wang J, Zhang Y, Ge S, Yuan Q, Cheng T, Guan Y, Xia N. Nasal irrigation efficiently attenuates SARS-CoV-2 Omicron infection, transmission and lung injury in the Syrian hamster model. iScience. 2022 Dec 22;25(12):105475. doi: 10.1016/j.isci.2022.105475. Epub 2022 Nov 2.
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Poon L, Gu H, Quadeer AA, Krishnan P, Chang L, Liu G, Ng D, Cheng S, Lam TT, Peiris M, McKay M. Within-host diversity of SARS-CoV-2 lineages and effect of vaccination. Res Sq [Preprint]. 2022 Aug 11:rs.3.rs-1927944. doi: 10.21203/rs.3.rs-1927944/v1.
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Cheng SS, Mok CK, Li JK, Ng SS, Lam BH, Jeevan T, Kandeil A, Pekosz A, Chan KC, Tsang LC, Ko FW, Chen C, Yiu K, Luk LL, Chan KK, Webby RJ, Poon LL, Hui DS, Peiris M. Plaque-neutralizing antibody to BA.2.12.1, BA.4 and BA.5 in individuals with three doses of BioNTech or CoronaVac vaccines, natural infection and breakthrough infection. J Clin Virol. 2022 Nov;156:105273. doi: 10.1016/j.jcv.2022.105273. Epub 2022 Aug 31.
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Hui KPY, Ng KC, Ho JCW, Yeung HW, Ching RHH, Gu H, Chung JCK, Chow VLY, Sit KY, Hsin MKY, Au TWK, Poon LLM, Peiris M, Nicholls JM, Chan MCW. Replication of SARS-CoV-2 Omicron BA.2 variant in ex vivo cultures of the human upper and lower respiratory tract. EBioMedicine. 2022 Sep;83:104232. doi: 10.1016/j.ebiom.2022.104232. Epub 2022 Aug 18.
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Cowling BJ, Cheng SMS, Martín-Sánchez M, Au NYM, Chan KCK, Li JKC, Fung LWC, Luk LLH, Tsang LCH, Ip DKM, Poon LLM, Leung GM, Peiris JSM, Leung NHL. Slow waning of antibodies following a third dose of BNT162b2 in adults who had previously received two doses of inactivated vaccine. J Infect Dis. 2022 Sep 15:jiac380. doi: 10.1093/infdis/jiac380. Epub ahead of print.
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Jia JZ, Tan CW, Cheng SMS, Gu H, Yeoh AYY, Mok CKP, Wang Y, Zhao J, Leung NHL, Cowling BJ, Poon LLM, Hui DSC, Wang L, Peiris M, Valkenburg SA. Priming conditions shape breadth of neutralizing antibody responses to sarbecoviruses. Nat Commun. 2022 Oct 21;13(1):6285. doi: 10.1038/s41467-022-34038-6.